We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ca(2+)/CaM-dependent kinases: from activation to function.
- Authors
Hook, S S; Means, A R
- Abstract
Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor for Ca(2+). The Ca(2+)/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cellular functions. Among the many Ca(2+)/CaM-binding proteins to be discovered, the multifunctional protein kinases CaMKI, II, and IV play pivotal roles. Our review focuses on this class of CaM kinases to illustrate the structural and biochemical basis for Ca(2+)/CaM interaction with and regulation of its target enzymes. Gene transcription has been chosen as the functional endpoint to illustrate the recent advances in Ca(2+)/CaM-mediated signal transduction mechanisms.
- Publication
Annual review of pharmacology and toxicology, 2001, Vol 41, p471
- ISSN
0362-1642
- Publication type
Journal Article
- DOI
10.1146/annurev.pharmtox.41.1.471