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- Title
Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence.
- Authors
Carlsson, A; Waters, N; Holm-Waters, S; Tedroff, J; Nilsson, M; Carlsson, M L
- Abstract
In spite of its proven heuristic value, the dopamine hypothesis of schizophrenia is now yielding to a multifactorial view, in which the other monoamines as well as glutamate and GABA are included, with a focus on neurotransmitter interactions in complex neurocircuits. The primary lesion(s) in schizophrenia does not necessarily involve any of these neurotransmitters directly but could deal with a more general defect, such as a faulty connectivity of developmental origin. Nevertheless, a precise identification of neurotransmitter aberrations in schizophrenia will probably provide clues for a better understanding of the disease and for the development of new treatment and prevention strategies.
- Publication
Annual review of pharmacology and toxicology, 2001, Vol 41, p237
- ISSN
0362-1642
- Publication type
Journal Article
- DOI
10.1146/annurev.pharmtox.41.1.237