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- Title
GUGULIPID: a natural cholesterol-lowering agent.
- Authors
Urizar, Nancy L; Moore, David D
- Abstract
The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids.
- Publication
Annual review of nutrition, 2003, Vol 23, p303
- ISSN
0199-9885
- Publication type
Journal Article
- DOI
10.1146/annurev.nutr.23.011702.073102