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- Title
Pain mechanisms: labeled lines versus convergence in central processing.
- Authors
Craig, A D Bud
- Abstract
The issue of whether pain is represented by specific neural elements or by patterned activity within a convergent somatosensory subsystem has been debated for over a century. The gate control theory introduced in 1965 denied central specificity, and since then most authors have endorsed convergent wide-dynamic-range neurons. Recent functional and anatomical findings provide compelling support for a new perspective that views pain in humans as a homeostatic emotion that integrates both specific labeled lines and convergent somatic activity.
- Publication
Annual review of neuroscience, 2003, Vol 26, p1
- ISSN
0147-006X
- Publication type
Journal Article
- DOI
10.1146/annurev.neuro.26.041002.131022