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- Title
Large-scale sources of neural stem cells.
- Authors
Gottlieb, David I
- Abstract
Large-scale sources of neural stem cells are crucial for both basic research and novel approaches toward treating neurological disorders. Three sources that produce neural cells closely resembling their normal counterparts are now available: oncogene immortalized stem cells, neurospheres, and embryonic stem cell (ES)-derived neural cells. Cells including multiple subtypes of CNS and PNS neurons, as well as oligodendrocytes, Schwann cells, and astrocytes, are modeled by these large-scale sources. Although most cell lines were originally from rodents, their human counterparts are being discovered and characterized.
- Publication
Annual review of neuroscience, 2002, Vol 25, p381
- ISSN
0147-006X
- Publication type
Journal Article
- DOI
10.1146/annurev.neuro.25.112701.142904