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- Title
Macrophage receptors and immune recognition.
- Authors
Taylor, P R; Martinez-Pomares, L; Stacey, M; Lin, H-H; Brown, G D; Gordon, S
- Abstract
Macrophages express a broad range of plasma membrane receptors that mediate their interactions with natural and altered-self components of the host as well as a range of microorganisms. Recognition is followed by surface changes, uptake, signaling, and altered gene expression, contributing to homeostasis, host defense, innate effector mechanisms, and the induction of acquired immunity. This review covers recent studies of selected families of structurally defined molecules, studies that have improved understanding of ligand discrimination in the absence of opsonins and differential responses by macrophages and related myeloid cells.
- Publication
Annual review of immunology, 2005, Vol 23, p901
- ISSN
0732-0582
- Publication type
Journal Article
- DOI
10.1146/annurev.immunol.23.021704.115816