We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Regulation of lymphoid development, differentiation, and function by the Notch pathway.
- Authors
Maillard, Ivan; Fang, Terry; Pear, Warren S
- Abstract
The Notch pathway is gaining increasing recognition as a key regulator of developmental choices, differentiation, and function throughout the hematolymphoid system. Notch controls the generation of hematopoietic stem cells during embryonic development and may affect their subsequent homeostasis. Commitment to the T cell lineage and subsequent stages of early thymopoiesis is critically regulated by Notch. Recent data indicate that Notch can also direct the differentiation and activity of peripheral T and B cells. Thus, the full spectrum of Notch effects is just beginning to be understood. In this review, we discuss this explosion of knowledge as well as current controversies and challenges in the field.
- Publication
Annual review of immunology, 2005, Vol 23, p945
- ISSN
0732-0582
- Publication type
Journal Article
- DOI
10.1146/annurev.immunol.23.021704.115747