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- Title
BAFF AND APRIL: a tutorial on B cell survival.
- Authors
Mackay, Fabienne; Schneider, Pascal; Rennert, Paul; Browning, Jeffrey
- Abstract
BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role. The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.
- Publication
Annual review of immunology, 2003, Vol 21, p231
- ISSN
0732-0582
- Publication type
Journal Article
- DOI
10.1146/annurev.immunol.21.120601.141152