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- Title
The regulatory role of Valpha14 NKT cells in innate and acquired immune response.
- Authors
Taniguchi, Masaru; Harada, Michishige; Kojo, Satoshi; Nakayama, Toshinori; Wakao, Hiroshi
- Abstract
A novel lymphocyte lineage, Valpha14 natural killer T (NKT) cells, is now well established as distinct from conventional alphabeta T cells. Valpha14 NKT cells express a single invariant Valpha14 antigen receptor that is essential for their development. Successful identification of a specific ligand, alpha-galactosylceramide(alpha-GalCer), and the establishment of gene-manipulated mice with selective loss of Valpha14 NKT cells helped elucidate the remarkable functional diversity of Valpha14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.
- Publication
Annual review of immunology, 2003, Vol 21, p483
- ISSN
0732-0582
- Publication type
Journal Article
- DOI
10.1146/annurev.immunol.21.120601.141057