We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Producing nature's gene-chips: the generation of peptides for display by MHC class I molecules.
- Authors
Shastri, Nilabh; Schwab, Susan; Serwold, Thomas
- Abstract
Gene-chips contain thousands of nucleotide sequences that allow simultaneous analysis of the complex mixture of RNAs transcribed in cells. Like these gene-chips, major histocompatibility complex (MHC) class I molecules display a large array of peptides on the cell surface for probing by the CD8(+) T cell repertoire. The peptide mixture represents fragments of most, if not all, intracellular proteins. The antigen processing machinery accomplishes the daunting task of sampling these proteins and cleaving them into the precise set of peptides displayed by MHC I molecules. It has long been believed that antigenic peptides arose as by-products of normal protein turnover. Recent evidence, however, suggests that the primary source of peptides is newly synthesized proteins that arise from conventional as well as cryptic translational reading frames. It is increasingly clear that for many peptides the C-terminus is generated in the cytoplasm, and N-terminal trimming occurs in the endoplasmic reticulum in an MHC I-dependent manner. Nature's gene-chips are thus both parsimonious and elegant.
- Publication
Annual review of immunology, 2002, Vol 20, p463
- ISSN
0732-0582
- Publication type
Journal Article
- DOI
10.1146/annurev.immunol.20.100301.064819