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- Title
Cross-presentation, dendritic cells, tolerance and immunity.
- Authors
Heath, W R; Carbone, F R
- Abstract
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.
- Publication
Annual review of immunology, 2001, Vol 19, p47
- ISSN
0732-0582
- Publication type
Journal Article
- DOI
10.1146/annurev.immunol.19.1.47