We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic analysis of B cell antigen receptor signaling.
- Authors
Kurosaki, T
- Abstract
In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these PTKs determine the quality and quantity of BCR signaling. For example, concerted actions of the PLC-gamma 2 and PI3-K pathways are required for proper calcium responses. Similarly, the regulation of ERK and JNK responses involves both PLC-gamma 2 and GTPases pathways. Since the immune response in vivo is regulated by alteration of these signaling outcomes, achieving a precise understanding of intracellular molecular events leading to B lymphocyte proliferation, deletion, anergy, receptor editing, and survival still remains a challenge for the future.
- Publication
Annual review of immunology, 1999, Vol 17, p555
- ISSN
0732-0582
- Publication type
Journal Article
- DOI
10.1146/annurev.immunol.17.1.555