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- Title
Error-prone DNA polymerases: when making a mistake is the only way to get ahead.
- Authors
Rattray, Alison J; Strathern, Jeffrey N
- Abstract
Cells have high-fidelity polymerases whose task is to accurately replicate the genome, and low-fidelity polymerases with specialized functions. Although some of these low-fidelity polymerases are exceptional in their ability to replicate damaged DNA and restore the undamaged sequence, they are error prone on undamaged DNA. In fact, these error-prone polymerases are sometimes used in circumstances where the capacity to make errors has a selective advantage. The mutagenic potential of the error-prone polymerases requires that their expression, activity, and access to undamaged DNA templates be regulated. Here we review these specialized polymerases with an emphasis on their biological roles.
- Publication
Annual review of genetics, 2003, Vol 37, p31
- ISSN
0066-4197
- Publication type
Journal Article
- DOI
10.1146/annurev.genet.37.042203.132748