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- Title
Mating-type gene switching in Saccharomyces cerevisiae.
- Authors
Haber, J E
- Abstract
Saccharomyces cerevisiae can change its mating type as often as every generation by a highly choreographed, site-specific recombination event that replaces one MAT allele with different DNA sequences encoding the opposite allele. The study of this process has yielded important insights into the control of cell lineage, the silencing of gene expression, and the formation of heterochromatin, as well as the molecular events of double-strand break-induced recombination. In addition, MAT switching provides a remarkable example of a small locus control region--the Recombination Enhancer--that controls recombination along an entire chromosome arm.
- Publication
Annual review of genetics, 1998, Vol 32, p561
- ISSN
0066-4197
- Publication type
Journal Article
- DOI
10.1146/annurev.genet.32.1.561