We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic analysis of the multidrug transporter.
- Authors
Gottesman, M M; Hrycyna, C A; Schoenlein, P V; Germann, U A; Pastan, I
- Abstract
The analysis of how human cancers evade chemotherapy has revealed a rich variety of cell-based genetic changes resulting in drug resistance. One of the best studied of these genetic alterations is increased expression of an ATP-dependent plasma membrane transport system, known as P-glycoprotein, or the multidrug transporter. This transporter actively effluxes a large number of natural product, hydrophobic, cytotoxic drugs, including many important anticancer agents. This review focuses on the genetic and molecular genetic analysis of the human multidrug transporter, including structure-function analysis, pre- and posttranslational regulation of expression, the role of gene amplification in increased expression, and the properties of transgenic and "knock-out" mice. One important feature of the MDR gene is its potential for the development of new selectable vectors for human gene therapy.
- Publication
Annual review of genetics, 1995, Vol 29, p607
- ISSN
0066-4197
- Publication type
Journal Article
- DOI
10.1146/annurev.ge.29.120195.003135