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- Title
Protein translocation by the Sec61/SecY channel.
- Authors
Osborne, Andrew R; Rapoport, Tom A; van den Berg, Bert
- Abstract
The conserved protein-conducting channel, referred to as the Sec61 channel in eukaryotes or the SecY channel in eubacteria and archaea, translocates proteins across cellular membranes and integrates proteins containing hydrophobic transmembrane segments into lipid bilayers. Structural studies illustrate how the protein-conducting channel accomplishes these tasks. Three different mechanisms, each requiring a different set of channel binding partners, are employed to move polypeptide substrates: The ribosome feeds the polypeptide chain directly into the channel, a ratcheting mechanism is used by the eukaryotic endoplasmic reticulum chaperone BiP, and a pushing mechanism is utilized by the bacterial ATPase SecA. We review these translocation mechanisms, relating biochemical and genetic observations to the structures of the protein-conducting channel and its binding partners.
- Publication
Annual review of cell and developmental biology, 2005, Vol 21, p529
- ISSN
1081-0706
- Publication type
Journal Article
- DOI
10.1146/annurev.cellbio.21.012704.133214