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- Title
The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.
- Authors
Näthke, Inke S
- Abstract
The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of -catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis. The gut epithelium is uniquely dependent on an intricate balance between a number of fundamental cellular processes including migration, differentiation, adhesion, apoptosis, and mitosis. In this review, I discuss the molecular mechanisms that govern the various functions of APC and their relationship to the role of APC in colon cancer.
- Publication
Annual review of cell and developmental biology, 2004, Vol 20, p337
- ISSN
1081-0706
- Publication type
Journal Article
- DOI
10.1146/annurev.cellbio.20.012103.094541