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- Title
RNA translation in axons.
- Authors
Piper, Michael; Holt, Christine
- Abstract
The cell body has classically been considered the exclusive source of axonal proteins. However, significant evidence has accumulated recently to support the view that protein synthesis can occur in axons themselves, remote from the cell body. Indeed, local translation in axons may be integral to aspects of synaptogenesis, long-term facilitation, and memory storage in invertebrate axons, and for growth cone navigation in response to environmental stimuli in developing vertebrate axons. Here we review the evidence supporting mRNA translation in axons and discuss the potential roles that local protein synthesis may play during development and subsequent neuronal function. We advance the view that local translation provides a rapid supply of nascent proteins in restricted axonal compartments that can potentially underlie long-term responses to transient stimuli.
- Publication
Annual review of cell and developmental biology, 2004, Vol 20, p505
- ISSN
1081-0706
- Publication type
Journal Article
- DOI
10.1146/annurev.cellbio.20.010403.111746