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- Title
SUMO--nonclassical ubiquitin.
- Authors
Melchior, F
- Abstract
SUMO (small ubiquitin-related modifier) is the best-characterized member of a growing family of ubiquitin-related proteins. It resembles ubiquitin in its structure, its ability to be ligated to other proteins, as well as in the mechanism of ligation. However, in contrast to ubiquitination-often the first step on a one-way road to protein degradation-SUMOlation does not seem to mark proteins for degradation. In fact, SUMO may even function as an antagonist of ubiquitin in the degradation of selected proteins. While most SUMO targets are still at large, available data provide compelling evidence for a role of SUMO in the regulation of protein-protein interactions and/or subcellular localization.
- Publication
Annual review of cell and developmental biology, 2000, Vol 16, p591
- ISSN
1081-0706
- Publication type
Journal Article
- DOI
10.1146/annurev.cellbio.16.1.591