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- Title
Initiation of DNA replication in eukaryotic cells.
- Authors
Dutta, A; Bell, S P
- Abstract
The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur throughout the cell cycle. Herein, we review the key proteins required for the initiation of DNA replication, their involvement in the protein complex assembly at replication origins, and how the cell cycle machinery regulates this process.
- Publication
Annual review of cell and developmental biology, 1997, Vol 13, p293
- ISSN
1081-0706
- Publication type
Journal Article
- DOI
10.1146/annurev.cellbio.13.1.293