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- Title
RNA folds: insights from recent crystal structures.
- Authors
Ferré-D'Amaré, A R; Doudna, J A
- Abstract
An RNA fold is the result of packing together two or more coaxial helical stacks. To date, four RNA folds have been determined at near-atomic resolution by X-ray crystallography: transfer RNA, the hammerhead ribozyme, the P4-P6 domain of the Tetrahymena group I intron, and the hepatitis delta virus ribozyme. All four folds result in RNAs that are considerably more compact than isolated A-form duplexes. These structures illustrate, to varying degrees, three modes of fold stabilization: association of complementary molecular surfaces, stabilization of close RNA packing by binding of cations, and stabilization through pseudoknotting.
- Publication
Annual review of biophysics and biomolecular structure, 1999, Vol 28, p57
- ISSN
1056-8700
- Publication type
Journal Article
- DOI
10.1146/annurev.biophys.28.1.57