We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Structural insights into the signal recognition particle.
- Authors
Doudna, Jennifer A; Batey, Robert T
- Abstract
The signal recognition particle (SRP) directs integral membrane and secretory proteins to the cellular protein translocation machinery during translation. The SRP is an evolutionarily conserved RNA-protein complex whose activities are regulated by GTP hydrolysis. Recent structural investigations of SRP functional domains and interactions provide new insights into the mechanisms of SRP activity in all cells, leading toward a comprehensive understanding of protein trafficking by this elegant pathway.
- Publication
Annual review of biochemistry, 2004, Vol 73, p539
- ISSN
0066-4154
- Publication type
Journal Article
- DOI
10.1146/annurev.biochem.73.011303.074048