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- Title
The RNA polymerase II core promoter.
- Authors
Smale, Stephen T; Kadonaga, James T
- Abstract
The events leading to transcription of eukaryotic protein-coding genes culminate in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which can extend ~35 bp upstream and/or downstream of this site, plays a central role in regulating initiation. Specific DNA elements within the core promoter bind the factors that nucleate the assembly of a functional preinitiation complex and integrate stimulatory and repressive signals from factors bound at distal sites. Although core promoter structure was originally thought to be invariant, a remarkable degree of diversity has become apparent. This article reviews the structural and functional diversity of the RNA polymerase II core promoter.
- Publication
Annual review of biochemistry, 2003, Vol 72, p449
- ISSN
0066-4154
- Publication type
Journal Article
- DOI
10.1146/annurev.biochem.72.121801.161520