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- Title
Mechanisms of viral membrane fusion and its inhibition.
- Authors
Eckert, D M; Kim, P S
- Abstract
Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical studies of two viral glycoproteins, influenza hemagglutinin and HIV-1 envelope protein, have led to a common model for viral entry. The fusion mechanism involves a transient conformational species that can be targeted by therapeutic strategies. This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible.
- Publication
Annual review of biochemistry, 2001, Vol 70, p777
- ISSN
0066-4154
- Publication type
Journal Article
- DOI
10.1146/annurev.biochem.70.1.777