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- Title
Anti-hypertension Effects of Traditional Chinese Medicine Ju-Ling-Tang on Renal Hypertensive Rats.
- Authors
Hung-Che Shih; Tzu-Hsin Lee; Shu-Chen Chen; Chien-Ying Li; Shibuya, Takeshi
- Abstract
This research investigated the anti-hypertension effect of the traditional Chinese medicine (TCM) Ju-Ling-Tang (JLT) on an animal model of hypertension induced by unilateral renal artery ligation. In the study of anti-hypertension effects, 60 minutes after oral administration with NG tube feeding of 240 mg/kg JLT, a significant decrease in blood pressure (p < 0.05) was observed and sustained till 120 minutes. In the group given 50 mg/kg α-methyldopa orally, the effect was obvious 90 minutes after medication (p < 0.01), and lasted until 240 minutes. In terms of organ pathology, a significant reduction in the extent of induced glomerular sclerosis was observed in rats given 240 mg/kg JLT compared with the control. From these results, we infer that JLT has a beneficial anti-hypertensive effect on renal hypertension.
- Publication
American Journal of Chinese Medicine, 2005, Vol 33, Issue 6, p913
- ISSN
0192-415X
- Publication type
Academic Journal
- DOI
10.1142/S0192415X05003545