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- Title
Antioxidative and free radical scavenging effects of ecdysteroids from Serratula strangulata.
- Authors
Yu-Jun Cai; Jin-Qiu Dai; Jian-Guo Fang; Lan-Ping Ma; Li-Fen Hou; Li Yang; Zhong-Li Liu
- Abstract
The antioxidative and free radical scavenging effects of four ecdysteroids, 20-hydroxyecdysone (E1), 25-deoxy-11,20-dihydroxyecdysone (E2), 24-(2-hydroxyethyl)-20-hydroxyecdysone (E3), and 20-hydroxyecdysone-20,22-monoacetonide (E4), isolated from the Chinese herb Serratula strangulata have been investigated in vitro. These ecdysteroids could protect human erythrocytes against oxidative hemolysis induced by a water-soluble azo initiator 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH). They could also inhibit the peroxidation of rat liver microsomes induced by hydroxyl radicals, as monitored by the formation of thiobarbituric acid reactive substances (TBARS), and prevent radical-induced decrease of membrane fluidity as determined by fluorescence polarization. They reacted with galvinoxyl radicals in homogeneous solution, and the pseudo-first-order rate constants were determined spectrophoto-metrically by following the disappearance of galvinoxyl radicals. Compounds E1 and (or) E3 were the most active in both antioxidative and radical-scavenging reactions.
- Publication
Canadian Journal of Physiology & Pharmacology, 2002, Vol 80, Issue 12, p1187
- ISSN
0008-4212
- Publication type
Academic Journal
- DOI
10.1139/y02-152