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- Title
ATP-dependent chromatin remodeling in T cells.
- Authors
Wurster, Andrea L; Pazin, Michael J
- Abstract
One of the best studied systems for mammalian chromatin remodeling is transcriptional regulation during T cell development. The variety of these studies have led to important findings in T cell gene regulation and cell fate determination. Importantly, these findings have also advanced our knowledge of the function of remodeling enzymes in mammalian gene regulation. First we briefly present biochemical and cell-free analysis of 3 types of ATP dependent remodeling enzymes (SWI/SNF, Mi2, and ISWI) to construct an intellectual framework to understand how these enzymes might be working. Second, we compare and contrast the function of these enzymes during early (thymic) and late (peripheral) T cell development. Finally, we examine some of the gaps in our present understanding.
- Publication
Biochemistry and cell biology = Biochimie et biologie cellulaire, 2012, Vol 90, Issue 1, p1
- ISSN
1208-6002
- Publication type
Journal Article
- DOI
10.1139/o11-042