We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Beyond apoptosis: nonapoptotic cell death in physiology and disease.
- Authors
Hetz, Claudio A; Torres, Vicente; Quest, Andrew F G
- Abstract
Apoptosis is a morphologically defined form of programmed cell death (PCD) that is mediated by the activation of members of the caspase family. Analysis of death-receptor signaling in lymphocytes has revealed that caspase-dependent signaling pathways are also linked to cell death by nonapoptotic mechanisms, indicating that apoptosis is not the only form of PCD. Under physiological and pathological conditions, cells demonstrate a high degree of flexibility in cell-death responses, as is reflected in the existence of a variety of mechanisms, including necrosis-like PCD, autophagy (or type II PCD), and accidental necrosis. In this review, we discuss recent data suggesting that canonical apoptotic pathways, including death-receptor signaling, control caspase-dependent and -independent cell-death pathways.
- Publication
Biochemistry and cell biology = Biochimie et biologie cellulaire, 2005, Vol 83, Issue 5, p579
- ISSN
0829-8211
- Publication type
Journal Article
- DOI
10.1139/o05-065