We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Integrative strategies to identify candidate genes in rodent models of human alcoholism.
- Authors
Treadwell, Julie A
- Abstract
The search for genes underlying alcohol-related behaviours in rodent models of human alcoholism has been ongoing for many years with only limited success. Recently, new strategies that integrate several of the traditional approaches have provided new insights into the molecular mechanisms underlying ethanol's actions in the brain. We have used alcohol-preferring C57BL/6J (B6) and alcohol-avoiding DBA/2J (D2) genetic strains of mice in an integrative strategy combining high-throughput gene expression screening, genetic segregation analysis, and mapping to previously published quantitative trait loci to uncover candidate genes for the ethanol-preference phenotype. In our study, 2 genes, retinaldehyde binding protein 1 (Rlbp1) and syntaxin 12 (Stx12), were found to be strong candidates for ethanol preference. Such experimental approaches have the power and the potential to greatly speed up the laborious process of identifying candidate genes for the animal models of human alcoholism.
- Publication
Genome, 2006, Vol 49, Issue 1, p1
- ISSN
0831-2796
- Publication type
Journal Article
- DOI
10.1139/g05-083