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- Title
Regulatory noncoding RNAs at Hox loci.
- Authors
Brock, Hugh W; Hodgson, Jacob W; Petruk, Svetlana; Mazo, Alexander
- Abstract
There is growing awareness of the importance of noncoding (nc)RNAs in the regulation of gene expression during pattern formation in development. Spatial regulation of Hox gene expression in development controls positional identity along the antero-posterior axis. In this review, we will focus on the role of short ncRNAs that repress Hox genes in Drosophila and mammals by RNA interference (RNAi), on long ncRNAs that may repress a Hox in cis in Drosophila by transcriptional interference, and on a novel long ncRNA that functions in trans to regulate Hox genes mammals.
- Publication
Biochemistry and cell biology = Biochimie et biologie cellulaire, 2009, Vol 87, Issue 1, p27
- ISSN
0829-8211
- Publication type
Journal Article
- DOI
10.1139/O08-108