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- Title
Minimisation of aminoglycoside toxicity in patients with cystic fibrosis.
- Authors
Wood, P J; Ioannides-Demos, L L; Li, S C; Williams, T J; Hickey, B; Spicer, W J; Hooper, R E; McLean, A J
- Abstract
There is evidence that administration of higher doses of aminoglycosides given less frequently improves the bactericidal effect and reduces the potential to cause side effects. To investigate this, a prospectively randomised open label therapeutic trial was undertaken in stratified groups of patients with cystic fibrosis to examine the efficacy and toxic potential of an aminoglycoside dosing regimen designed to generate high peak drug concentrations at 12 hourly intervals compared with conventional dosing at eight hourly intervals.
- Publication
Thorax, 1996, Vol 51, Issue 4, p369
- ISSN
0040-6376
- Publication type
Journal Article
- DOI
10.1136/thx.51.4.369