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Title
Effect of Mycobacterium tuberculosis and its components on macrophages and the release of matrix metalloproteinases.
Authors
Chang, J C; Wysocki, A; Tchou-Wong, K M; Moskowitz, N; Zhang, Y; Rom, W N
Abstract
Pulmonary tuberculosis is associated with caseating necrosis, parenchymal lung destruction, and cavity formation. It was hypothesised that tuberculous lung destruction is mediated, at least in part, by the participation of matrix metalloproteinases released by mononuclear phagocytes.