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Title
Angiotensin converting enzyme (ACE) inhibitor-induced cough and substance P.
Authors
Tomaki, M; Ichinose, M; Miura, M; Hirayama, Y; Kageyama, N; Yamauchi, H; Shirato, K
Abstract
Angiotensin converting enzyme (ACE) inhibitors cause coughing in 5-10% of patients, but the exact mechanisms of this effect are still unclear. In the airways ACE degrades substance P so the cough mechanism may be related to this peptide.