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- Title
Controlled trial of cycled antibiotic prophylaxis to prevent initial Pseudomonas aeruginosa infection in children with cystic fibrosis.
- Authors
Tramper-Stranders, Gerdien A; Wolfs, Tom F W; van Haren Noman, Sanne; van Aalderen, Wim M C; Nagelkerke, Ad F; Nuijsink, Marianne; Kimpen, Jan L L; van der Ent, Cornelis K
- Abstract
Initial pulmonary Pseudomonas aeruginosa infection in patients with cystic fibrosis (CF) is currently treated with intensive antibiotic therapy. At this stage, inflammation and tissue injury might have already occurred. Moreover, bacterial eradication is not always achieved. Prophylactic treatment against P aeruginosa seemed to have a preventive effect in retrospective studies. A study was undertaken to establish prospectively the effect of cycled prophylactic treatment on prevention of initial P aeruginosa infection in children with CF.
- Publication
Thorax, 2010, Vol 65, Issue 10, p915
- ISSN
1468-3296
- Publication type
Journal Article
- DOI
10.1136/thx.2009.126128