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- Title
Increased levels of cysteinyl-leukotrienes in saliva, induced sputum, urine and blood from patients with aspirin-intolerant asthma.
- Authors
Gaber, F; Daham, K; Higashi, A; Higashi, N; Gülich, A; Delin, I; James, A; Skedinger, M; Gyllfors, P; Nord, M; Dahlén, S-E; Kumlin, M; Dahlén, B
- Abstract
A diagnosis of aspirin-intolerant asthma requires aspirin provocation in specialist clinics. Urinary leukotriene E(4) (LTE(4)) is increased in aspirin-intolerant asthma. A study was undertaken to investigate new biomarkers of aspirin intolerance by comparing basal levels of cysteinyl-leukotrienes (CysLTs) and leukotriene B(4) (LTB(4)) in saliva, sputum and ex vivo stimulated blood in subjects with aspirin-intolerant and aspirin-tolerant asthma. The effects of aspirin- and allergen-induced bronchoconstriction on leukotriene levels in saliva and ex vivo stimulated blood were also compared with the effects of the provocations on urinary mediators.
- Publication
Thorax, 2008, Vol 63, Issue 12, p1076
- ISSN
1468-3296
- Publication type
Journal Article
- DOI
10.1136/thx.2008.101196