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- Title
Performance of a whole blood interferon gamma assay for detecting latent infection with Mycobacterium tuberculosis in children.
- Authors
Connell, T G; Curtis, N; Ranganathan, S C; Buttery, J P
- Abstract
The diagnosis of latent Mycobacterium tuberculosis (MTB) infection with a tuberculin skin test (TST) in children is complicated by the potential influence of prior exposure to Bacille Calmette Geurin (BCG) vaccination or environmental mycobacteria. A whole blood assay has recently been developed to quantitatively measure interferon gamma (IFN-gamma) production by lymphocytes specific to the MTB antigens ESAT-6 and CFP-10, but its use and assessment in children has been limited. A study was undertaken to compare the performance of the whole blood IFN-gamma assay with the TST in diagnosing latent tuberculosis (TB) infection or TB disease in children in routine clinical practice.
- Publication
Thorax, 2006, Vol 61, Issue 7, p616
- ISSN
0040-6376
- Publication type
Journal Article
- DOI
10.1136/thx.2005.048033