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- Title
BCG protects against tuberculosis irrespective of HIV status: a matched case-control study in Mwanza, Tanzania.
- Authors
Faurholt-Jepsen, Daniel; Range, Nyagosya; Praygod, George; Jeremiah, Kidola; Faurholt-Jepsen, Maria; Aabye, Martine G; Grewal, Harleen M S; Changalucha, John; Witte, Daniel R; Andersen, Aase B; Friis, Henrik
- Abstract
While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.
- Publication
Thorax, 2013, Vol 68, Issue 3, p288
- ISSN
1468-3296
- Publication type
Commentary
- DOI
10.1136/thoraxjnl-2012-201971