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- Title
Proteolytic activity in cowshed dust extracts induces C5a release in murine bronchoalveolar lavage fluids which may account for its protective properties in allergic airway inflammation.
- Authors
Stiehm, Matthias; Bufe, Albrecht; Peters, Marcus
- Abstract
Intranasal application of cowshed dust extract (CDE) during sensitisation in a murine model of experimental asthma leads to a significant alleviation of the clinical parameters of the allergic immune response. However, neither the immunological mechanisms underlying this protective effect nor all of the protective substances included in CDE have yet been described. Recently, complement factor 5a (C5a) receptor signalling has been identified to play a regulatory role in allergic airway disease. Thus we investigated whether CDE can activate the complement system to release biologically active C5a in the lung.
- Publication
Thorax, 2013, Vol 68, Issue 1, p31
- ISSN
1468-3296
- Publication type
Journal Article
- DOI
10.1136/thoraxjnl-2012-201746