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- Title
Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease.
- Authors
Huang, Jeffrey T J; Chaudhuri, Rekha; Albarbarawi, Osama; Barton, Alun; Grierson, Christal; Rauchhaus, Petra; Weir, Christopher J; Messow, Martina; Stevens, Nicola; McSharry, Charles; Feuerstein, Giora; Mukhopadhyay, Somnath; Brady, Jeffrey; Palmer, Colin N A; Miller, Douglas; Thomson, Neil C
- Abstract
Although an increased concentration of degraded elastin products in patients with chronic obstructive pulmonary disease (COPD) has been reported for many years, its clinical validity and utility remain uncertain due to technical difficulties, small study groups and the unknown relationship between exacerbation and elastin degradation. The objectives of this study were to determine the validity of urinary and blood total desmosine/isodesmosine in patients with COPD and asthma and to evaluate their relationship to exacerbation status and lung function.
- Publication
Thorax, 2012, Vol 67, Issue 6, p502
- ISSN
1468-3296
- Publication type
Journal Article
- DOI
10.1136/thoraxjnl-2011-200279