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- Title
Glial fibrillary acidic protein in late life major depressive disorder: an immunocytochemical study.
- Authors
Davis, S; Thomas, A; Perry, R; Oakley, A; Kalaria, R N; O'Brien, J T
- Abstract
Depression is a common psychiatric disorder in late life. Cerebrovascular disease has been postulated as an important aetiological factor in many cases (the "vascular depression" hypothesis). Consistent with this, an inflammatory response, most probably representing ischaemia, has been reported with increases in intercellular adhesion molecule 1 (ICAM-1), in the dorsolateral prefrontal cortex (DLPFC) in postmortem tissue from elderly depressed subjects. As ischaemia is known to cause astrogliosis, this study has further tested the "vascular depression hypothesis" by investigating the distribution of the astrocytic marker glial fibrillary acidic protein (GFAP) in the DLPFC and in the anterior cingulate cortex (ACC).
- Publication
Journal of neurology, neurosurgery, and psychiatry, 2002, Vol 73, Issue 5, p556
- ISSN
0022-3050
- Publication type
Journal Article
- DOI
10.1136/jnnp.73.5.556