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- Title
Slowing of central conduction in X-linked Charcot-Marie-Tooth neuropathy shown by brain stem auditory evoked responses.
- Authors
Nicholson, G; Corbett, A
- Abstract
The most common form of CMT with slow nerve conduction velocities (CMT type I) is CMT1A, caused by a submicroscopic duplication of a region of DNA on chromosome 17 including the PMP22 gene. This gene is expressed in peripheral nerve but not in the CNS. The second most common form is CMTX, caused by mutations in the connexin32 gene in the X chromosome. Connexin32 is expressed both in brain and in peripheral nerve. These molecular variants are difficult to distinguish clinically.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 1996, Vol 61, Issue 1, p43
- ISSN
0022-3050
- Publication type
Journal Article
- DOI
10.1136/jnnp.61.1.43