We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Double blind study of intrathecal beta-interferon in multiple sclerosis: clinical and laboratory results.
- Authors
Milanese, C; Salmaggi, A; La Mantia, L; Campi, A; Eoli, M; Savoiardo, M; Bianchi, G; Nespolo, A
- Abstract
Sixteen patients with clinically definite MS admitted to a double blind randomised controlled trial of intrathecal natural beta-IFN were followed for a mean of 22 months including the six month treatment period. Clinical response, evaluated in terms of relapse frequency and of progression rate, showed an increase in relapse rate in treated patients during the six month treatment period and, overall, no benefit in treated versus placebo patients. Serial evaluations were made of cerebrospinal fluid (CSF) cells, IgG, myelin basic protein and CSF and blood T-cell subsets. A rise in CSF IgG Index, MBP and DR+ cells in IFN-treated patients suggested an activation of intrathecal immune response in treated patients.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 1990, Vol 53, Issue 7, p554
- ISSN
0022-3050
- Publication type
Journal Article
- DOI
10.1136/jnnp.53.7.554