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- Title
L-dopa and arousal.
- Authors
Horvath, T B; Meares, R A
- Abstract
In 10 patients with Parkinsonism, treatment with L-dopa was associated with a rise in the skin conductance level and its fluctuations, an increased electromyographic activity in the frontalis muscle, and with faster reaction times. The change of skin conductance in response to a loud noise also increased and its habituation to the repetition of the stimulus was delayed. One patient developed a schizophreniform psychosis and showed high arousal and absent habituation. It is possible that dopamine is the transmitter associated with the arousal reaction and that it plays a part in the pathogenesis of schizophrenia.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 1974, Vol 37, Issue 4, p416
- ISSN
0022-3050
- Publication type
Journal Article
- DOI
10.1136/jnnp.37.4.416