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- Title
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations.
- Authors
Gouw, Alida A; Seewann, Alexandra; van der Flier, Wiesje M; Barkhof, Frederik; Rozemuller, Annemieke M; Scheltens, Philip; Geurts, Jeroen J G
- Abstract
White matter hyperintensities (WMH), lacunes and microbleeds are regarded as typical MRI expressions of cerebral small vessel disease (SVD) and they are highly prevalent in the elderly. However, clinical expression of MRI defined SVD is generally moderate and heterogeneous. By reviewing studies that directly correlated postmortem MRI and histopathology, this paper aimed to characterise the pathological substrates of SVD in order to create more understanding as to its heterogeneous clinical manifestation.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 2011, Vol 82, Issue 2, p126
- ISSN
1468-330X
- Publication type
Journal Article
- DOI
10.1136/jnnp.2009.204685