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Title
SPG10 is a rare cause of spastic paraplegia in European families.
Authors
Schüle, R; Kremer, B P H; Kassubek, J; Auer-Grumbach, M; Kostic, V; Klopstock, T; Klimpe, S; Otto, S; Boesch, S; van de Warrenburg, B P; Schöls, L
Abstract
SPG10 is an autosomal dominant form of hereditary spastic paraplegia (HSP), which is caused by mutations in the neural kinesin heavy chain KIF5A gene, the neuronal motor of fast anterograde axonal transport. Only four mutations have been identified to date.
Publication
Journal of neurology, neurosurgery, and psychiatry, 2008, Vol 79, Issue 5, p584