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- Title
Regional grey matter atrophy in clinically isolated syndromes at presentation.
- Authors
Henry, R G; Shieh, M; Okuda, D T; Evangelista, A; Gorno-Tempini, M L; Pelletier, D
- Abstract
The presence and degree of neuronal degeneration already existing in patients at their initial presentation with a clinically isolated syndrome suggestive of multiple sclerosis (CIS) is unclear, and whole brain or whole normalised grey matter analyses have not demonstrated significant atrophy in CIS cohorts at clinical presentation. Voxel-based analyses allow detection of regional atrophy throughout the brain and, therefore, may be sensitive to regional atrophy in CIS patients, and these changes may correspond with clinical disability.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 2008, Vol 79, Issue 11, p1236
- ISSN
1468-330X
- Publication type
Journal Article
- DOI
10.1136/jnnp.2007.134825