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- Title
Fatigue is associated with cerebral white matter hyperintensities in patients with systemic lupus erythematosus.
- Authors
Harboe, E; Greve, O J; Beyer, M; Gøransson, L G; Tjensvoll, A B; Maroni, S; Omdal, R
- Abstract
Fatigue is a disabling phenomenon in many patients who have systemic lupus erythematosus (SLE). The pathophysiological processes are unknown, and no known biological disease factors influence the phenomenon. Because depressive mood is consistently associated with fatigue, and drug treatment for SLE does not ameliorate fatigue, a psychological explanation could be an alternative. In search of a somatic basis for fatigue, we looked for alternative markers of biologic activity associated with fatigue. Cerebral white matter hyperintensities (WMHs) represent biochemical changes of brain tissue and are frequently encountered in patients with SLE, and are associated with cognitive impairment in patients with multiple sclerosis. Presence of such an association between fatigue and WMHs in SLE would favour a biological axis to fatigue.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 2008, Vol 79, Issue 2, p199
- ISSN
1468-330X
- Publication type
Journal Article
- DOI
10.1136/jnnp.2007.120626