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- Title
Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease.
- Authors
Bossù, Paola; Ciaramella, Antonio; Moro, Maria Luisa; Bellincampi, Lorenza; Bernardini, Sergio; Federici, Giorgio; Trequattrini, Alberto; Macciardi, Fabio; Spoletini, Ilaria; Di Iulio, Fulvia; Caltagirone, Carlo; Spalletta, Gianfranco
- Abstract
Inflammation has been extensively implicated in the pathogenesis of Alzheimer's disease (AD). Although there is evidence of a key role for cytokines in neuroinflammation processes, so far the proinflammatory cytokine interleukin (IL)-18 has not been associated with AD. The aim of this study was to investigate the impact of two polymorphisms of the human IL-18 gene promoter at positions -607 (C/A) and -137 (G/C) on both susceptibility to and progression of AD.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 2007, Vol 78, Issue 8, p807
- ISSN
1468-330X
- Publication type
Journal Article
- DOI
10.1136/jnnp.2006.103242