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- Title
Insulin-like growth factor I promoter polymorphism, risk of stroke, and survival after stroke: the Rotterdam study.
- Authors
van Rijn, M J E; Slooter, A J C; Bos, M J; Catarino, C F B S; Koudstaal, P J; Hofman, A; Breteler, M M B; van Duijn, C M
- Abstract
Low levels of insulin-like growth factor I (IGF-I) predispose to atherosclerosis and may therefore increase the risk of stroke. Low levels have also been found to influence the outcome of cardiovascular and cerebrovascular disease. A polymorphism in the promoter region of the IGF-I gene influences IGF-I levels. Non-carriers of the 192 bp allele have lower levels of IGF-I compared with 192 bp allele carriers. We studied the IGF-I polymorphism in relation to the risk of stroke and survival after stroke.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 2006, Vol 77, Issue 1, p24
- ISSN
0022-3050
- Publication type
Journal Article
- DOI
10.1136/jnnp.2005.067447