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- Title
Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography.
- Authors
Wolk, David A; Zhang, Zheng; Boudhar, Sanaa; Clark, Christopher M; Pontecorvo, Michael J; Arnold, Steven E
- Abstract
Amyloid imaging provides in vivo detection of the fibrillar amyloid-β (Aβ) plaques of Alzheimer's disease (AD). The positron emission tomography (PET) ligand, Pittsburgh Compound-B (PiB-C11), is the most well studied amyloid imaging agent, but the short half-life of carbon-11 limits its clinical viability. Florbetapir-F18 recently demonstrated in vivo correlation with postmortem Aβ histopathology, but has not been directly compared with PiB-C11.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 2012, Vol 83, Issue 9, p923
- ISSN
1468-330X
- Publication type
Journal Article
- DOI
10.1136/jnnp-2012-302548